2025 Nobel Prize in Physiology awarded to three scientists for immune tolerance discoveries

The Nobel Assembly at Karolinska Institutet announced today the 2025 Nobel Prize in Physiology or Medicine, awarding three scientists for their groundbreaking discoveries in peripheral immune tolerance. This research is significant as it prevents the immune system from attacking the body and offers potential treatments for autoimmune diseases.

The laureates are:

• Mary Brunkow (USA), recognized for her identification of the FOXP3 gene"s role in regulatory T cells.
• Fred Ramsdell (USA), honored for linking FOXP3 mutations to IPEX syndrome.
• Shimon Sakaguchi (Japan), acknowledged for elucidating the suppressive function of regulatory T cells.

Their contributions have transformed the field of immunology, facilitating the development of targeted therapies for conditions such as rheumatoid arthritis and multiple sclerosis. The Nobel Prize, valued at 11 million Swedish kronor to be shared among the winners, underscores the importance of foundational research in advancing global health.

For more information on recent developments in politics, see previous reports regarding political changes in France.